Trade card advertising Ayer's Ague Cure featuring a landscape image of a tropical place containing trees and foliage, a log cabin, two people and a heron-looking bird on the shore, and a person in a row boat. In the bottom right is a magnified view of an alligator or crocodile seemingly conversing with two frogs, one of which is holding a bottle and the other one of which is leaning on a box with the writing Ayer's Ague Cure on it. The back has an image of a bottle labeled Ayer's Ague Cure that is upright on a lilly pad with a frog standing on its back legs while touching the bottle with its front legs. The text lists the ailments Ayer's Ague Cure treats.